People

Nicholas Keith

Nicholas Keith

Graduate Student

nkeith3@jhmi.edu

Modell Lab

Publications

A dynamic subpopulation of CRISPR-Cas overexpressers allows Streptococcus pyogenes to rapidly respond to phage

Marie J. Stoltzfus, Rachael E. Workman, Nicholas C. Keith, Joshua W. Modell bioRxiv 2024.01.11.575229; doi: https://doi.org/10.1101/2024.01.11.575229 [preprint]

Anti-CRISPR proteins trigger a burst of CRISPR-Cas9 expression that enhances phage defense

Stoltzfus MJ, Workman RE, Keith NC, Modell JW. A dynamic subpopulation of CRISPR-Cas overexpressers allows Streptococcus pyogenes to rapidly respond to phage. Nat Microbiol. 2024 Sep;9(9):2410-2421. doi: 10.1038/s41564-024-01748-0. Epub 2024 Jul 12. PMID: 38997519; PMCID: PMC11983678.

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