People

Margaret Strong

Margaret Strong

mstrong@jhmi.edu (410) 614-1469

Regot Lab

Publications

TIN2 functions with TPP1/POT1 to stimulate telomerase processivity.

Pike AM, Strong MA, Ouyang JPT, Greider CW. (2019) TIN2 functions with TPP1/POT1 to stimulate telomerase processivity. American Society for Microbiology ASM:doi: https://doi.org/10.1128/MCB.00593-18. [ link ] [ pdf ]

Diagnostic utility of telomere length testing in a hospital-based setting

Jonathan K. Alder, Vidya Sagar Hanumanthu, Margaret A. Strong, Amy E. DeZern, Susan E. Stanley, Clifford M. Takemoto, Ludmilla Danilova, Carolyn D. Applegate, Stephen G. Bolton, David W. Mohr, Robert A. Brodsky, James F. Casella, Carol W. Greider, J. Brooks Jackson and Mary Armanios. (2018) Diagnostic utility of telomere length testing in a hospital-based setting. PNAS 115 (10): E2358-E2365 [ link ] [ pdf ]

BRD4 inhibitors block telomere elongation

Wang, S., Pike, A. M., Lee, S. S., Strong, M.A., Connelly, C.J., Greider, C.W. (2017) BRD4 inhibitors block telomere elongation. Nucleic Acids Research. 45(14): 8403-8410. [ link ] [ pdf ]

Strong, M.A.,Vidal-Cardenas, S.L., Karim, B., Yu, H., Guo, N., Greider, C.W., (2011). Phenotypes in mTERT+/- and mTERT-/- Mice are Due to Short Telomeres, Not Telomere-Independent Functions of TERT

Strong MA, Vidal-Cardenas SL, Karim B, Yu H, Guo N, Greider CW. (2011) Phenotypes in mTERT+/- and mTERT-/- Mice are Due to Short Telomeres, Not Telomere-Independent Functions of TERT. Molecular and Cellular Biology 31: 2369-2379. [ link ]

The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability.

Hemann, M.T., Strong, M., Hao, L.-Y., and Greider, C.W. (2001) The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107: 66-77. [ pdf ]

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