People

Yanshu Wang

Yanshu Wang

ywang@jhmi.edu (410) 955-4680

Nathans Lab

Jeremy Nathans

Publications

The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development.

Wang Y, Venkatesh A, Xu J, Xu M, Williams J, Smallwood PM, James A, Nathans J. The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development. Development. 2022 May 1;149(9):dev200340. doi: 10.1242/dev.200340. Epub 2022 May 12. Link

A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy

Wang Y, Smallwood PM, Williams J, Nathans J. (2020) A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy. Human Molecular Genetics. (7):1121-1131. doi: 10.1093/hmg/ddaa018. PMID: 31993640 [link]

Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development

Cho, C., Wang, Y., Smallwood, P.M., Williams, J., Nathans, J. (2019) Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development.  eLife 8: e47300. [ pdf ]

Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers

Cho C., Wang Y., Smallwood P.M., Williams J., Nathans J. (2019) Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers. eLife 2019;8:e45542 doi: 10.7554/eLife.45542. [ link ] [ pdf ]

Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures

Wang, Y, Sabbagh, MF,  Gu, X, Rattner, A, Williams, J, and Nathans, J. (2019) Beta-catenin signaling regu lates barrier-specific gene expression in circumventricular organ and ocular vasculatures.  eLife 8: e43257. [ pdf ]

Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance

Wang, Y., Cho, C., Williams, J., Smallwood, P.M., Zhang, C.,  Junge, H.J., and Nathans, J. (2018) Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance. Proceedings of the National Academy of Sciences USA 15: E11827-E11836. [ pdf ]

Frizzled receptors in development and disease

Wang, Y., Chang, H., Rattner, A., and Nathans, J. (2016) Frizzled receptors in development and disease. Current Topics in Developmental Biology 117: 113-139. [ pdf ]

Patterning of papillae on the mouse tongue: A system for the quantitative assessment of planar cell polarity signaling

Wang, Y., Williams, J., Rattner, A., Wu, S., Bassuk, A.G., Goffinet, A.M., and Nathans, J. (2016) Patterning of papillae on the mouse tongue: A system for the quantitative assessment of planar cell polarity signaling.  Developmental Biology 419: 298-310. [ pdf ]

Identification of Astrotactin2 as a genetic modifier that regulates the global orientation of mammalian hair follicles

Chang, H., Cahill, H., Smallwood, P.M., Wang, Y., and Nathans, J. (2015) Identification of Astrotactin2 as a genetic modifier that regulates the global orientation of mammalian hair follicles. PLOS Genetics 11: e1005532. [ pdf ]

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